verb/fastiˈdjaɾ/
to cloy; to annoy, to bother, to pester; to ruin; to disappoint
“El nuevo novio de mi mejor amiga me fastidia más que la voz de aquella cantante quejumbrosa que le gusta a ella.” — My best friend's new boyfriend annoys me more than the voice of that whiney singer she likes.
Synonyms: empalagar, fregar, joder, jorobar, molestar, decepcionar, desilusionar, desengañar
Borrowed from Latin fastidiō (“to be disgusted”), from fastidium. Compare the inherited doublet hastiar.