verb/saˌkaɾ de ˈkiθjo/
to rile up, to annoy; to drive crazy; to drive someone nuts; to cause somebody to come unhinged; to blow out of proportion
“Los llantos constantes de los bebés sacan de quicio a todos en el avión.” — The constant crying of the babies drives everyone nuts on the plane.
Literally, “to remove from [the] (door) jamb”.