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7,153 words — headwords with part of speech, pronunciation, and a plain-language definition.

sápido: tasty (having a taste)
sármata: Sarmatian
sármata: Sarmatian
sátira: satire
sátiro: satyr
sátiva: sativa, Cannabis sativa, drug made from the dried leaves and flowers of the hemp plant
sátrapa: satrap (governor of a Persian province); person that governs in a despotic and arbitrary fashion, usually making ostentation of their power
sávila: alternative spelling of sábila
sé: yes
sécuanos: Sequani
sémola: semolina, grits, meal (coarsely ground cereal)
sénior: senior
sénior: senior
sépalo: sepal
séptico: septic
séptimo: seventh
séptimo: seventh, ¹⁄₇
séptimo cielo: seventh heaven
séptuple: septuple
séquel: sheqel
séquito: entourage, retinue
sérico: silk; silky; serum
sérum: serum
sésamo: sesame (tropical Asian plant Sesamum indicum); sesame, sesame seed (the seed of this plant)
sésil: sessile
séxtuple: sextuple, six-time; six-part
séxtuple: sextuple
sí: prepositional form of se
sí: hello? (used when answering a phone call)
sí: yes; aye, ay; approbation, acceptance
sí mismo: oneself
sí o sí: definitely, no matter what
sí soy: used as a response when relating to something; that's me, me, relatable
sí y no: yes and no (when answering a yes-no question, implies that the answer is relative and may be both yes and no); Used other than figuratively or idiomatically: see sí, y, no.
sículo: Sicilian
sículo: Sicilian
sífilis: syphilis
sígnico: sign; signage
sílaba: syllable
sílabo: syllabus
sílex: flint
sílfide: sylph
sílice: silica
símbolo: symbol; creed
símbolo niceno: the Nicene Creed
símbolo sexual: sex symbol
símico: simian
símil: similar
símil: simile
símplex: simplex
símplice: simplex
síncopa: syncope
síncope: syncope
síncrono: synchronous
síndico: syndic; receiver (person who acts as trustee for a bankrupt); municipal mayor, head of a sindicatura, or municipal subdivision in Sinaloa and Sonora.
síndrome: syndrome
síndrome X frágil: fragile X syndrome
síndrome de Adie: Adie syndrome
síndrome de Aicardi: Aicardi syndrome
síndrome de Alagille: Alagille syndrome