Saint Petersburg (a federal city of Russia, known between 1914 and 1924 as Petrograd and between 1924 and 1991 as Leningrad; the former capital of Russia, from 1713–1728 and 1732–1918)
San Sebastián (a coastal city and municipality, the capital of the province of Gipuzkoa in the Basque Country, northern Spain); San Sebastián (a town and municipality of San Vicente department, El Salvador)
Saint Valentine's Day (a holiday in remembrance of Saint Valentine, February 14th, celebrated by sending cards or similar tokens of love); Saint Valentine
Saint Vincent and the Grenadines (an archipelago and country in the Caribbean, comprising the islands of Saint Vincent and the island chain of the Grenadines)
Santa Cruz de Tenerife (the capital and largest city of the province of Santa Cruz de Tenerife, Canary Islands, Spain; the co-capital of the Canary Islands, along with Las Palmas); Santa Cruz de Tenerife (a province of the Canary Islands)
Santa Fe (the capital city of New Mexico and the county seat of Santa Fe County); Santa Fe (a province in the center-east of Argentina); Santa Fe (the capital city of the province of Santa Fe, Argentina); in full, Santa Fe de la Vera Cruz; Santa Fe (several other places in Bolivia, Colombia, Chile, Cuba, Honduras, Panama, the Philippines, Spain and the United States)