defenestrar

Literally means to throw someone out of a window, but is used almost entirely in its figurative political/institutional sense — to abruptly remove someone from power or a position (defenestrar a un ministro, defenestrar al entrenador). It's dramatic, journalistic vocabulary, not a verb for ordinary firings.

• El presidente defenestró a tres ministros en una semana. — The president ousted three ministers in a week.
• Los accionistas defenestraron al director ejecutivo. — The shareholders ousted the CEO.
• Amenazaron con defenestrarlo si perdía otro partido. — They threatened to oust him if he lost another match.

Learners sometimes use this for any ordinary firing or resignation — reserve it for a dramatic, forced removal from a position of power, not a routine job change.

• politics Defenestración de Praga — The 1618 event in which Bohemian Protestant nobles threw two Catholic imperial governors and their secretary out of a window of Prague Castle — the spark that triggered the Thirty Years' War.