désopiler

Rare as a conjugated verb — almost all real usage is the adjective désopilant(e), meaning hilarious or side-splitting. The archaic literal sense was 'to clear an obstruction of the spleen,' which is where the odd word history comes from; the figurative sense of uncontrollable laughter has almost entirely replaced it.

• Ce sketch a désopilé toute la salle. — That sketch had the whole room in stitches.
• Son humour désopile même les plus sérieux. — His humor cracks up even the most serious people.
• La scène a désopilé les spectateurs pendant de longues minutes. — The scene had the audience in stitches for several minutes.

Don't expect to hear this verb conjugated in everyday speech — French speakers say 'c'est désopilant' (the adjective) far more often than any active form of désopiler.